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Vaccine therapy

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Pages: 256

Book format: An electronic version of a printed book that can be read on a computer or handheld device designed specifically for this purpose.

Publisher: Date:8/4/2009 - General Books LLC

By: Richard William Allen

Excerpt from book: CHAPTER II THE VALUE OF OP80NIC INDEX ESTIMATIONS IN DIAGNOSIS, PKOGNOSIS, AND TREATMENT It little matters what objections may be urged theoretically against the various procedures for estimating the opsonin content of the serum or the haemophagocytic power of the blood if the practical advantages derived from their application are real ones and commensurate with the time and labour involved. As we have already discussed the theoretical objeotions, it now behoves us to learn what practical lessons and advantages are to be derived from such investigations. To this end it is necessary to ascertain if any variations are to be detected in the blood of diseased individuals as compared with that of healthy ones : if such variations do exist, to learn their import: the bearing that they have on the clinical condition of the patient, and how they are to be controlled and influenced to his advantage. Inasmuch as by far the most thorough investigations upon these points have been conducted by means of opsonic index estimations, it is obviously best to devote our attention to this particular method. The Opsonic Index In Health. Firstly, we must consider whether the opsonic indices of all ' normal' individuals are the same, or whether theyexhibit variations, and, if so, to what factors are these variations to be attributed. We have seen that, in addition to the errors inherent in the method, numerous sources of error may be introduced into the evaluation of the opsonic index by Wright's method: that how great these will be depends on the skill, technique, and experience of the worker: and that in thoroughly competent hands the margin of error should not exceed 10 per cent. If we allow a margin of error of 10 per cent. in either direction, and assume that the blood of all nor...  


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